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Article Number: PP0277
Delivery time: 一周
Price: 1900/10 mL 15000/100 mL
Category:
Target: BOB.1
Application: IHC
Reactivity : Human,Mouse
Host Species: Mouse
Isotype : IgG2a, Kappa
隐藏域元素占位
Detailed Information
Purification process : The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage : 2°C to 8°C/1 year
Clonality : Monoclonal
Antigen & Target Information
Specificity : The antibody can specifically recognize human BOB.1 protein.
Gene name : POU2AF1 OBF1
Protein Name : POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1)
Alias : POU domain class 2-associating factor 1; B-cell-specific coactivator OBF-1; BOB-1; OCA-B; OCT-binding factor 1;
Background:
disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.,function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the POU2AF1 family.,tissue specificity:B-cell specific.,


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