Signaling pathway

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PD-1 (ABT-PD1) mouse mAb

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Article Number: PH0247
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: PD1
Application: IHC, ELISA
Reactivity : Human,
MW(CalcμLated) : 32 kD
MW(Observed) : 56 kD
Host Species: Mouse
Isotype : IgG1, Kappa

隐藏域元素占位

Detailed Information

Recommended dilution ratio : IHC 1:200-400; ELISA 1:500-5000
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clonality : Monoclonal
Clone Number : ABT-PD1

Antigen & Target Information

Specificity : The antibody can specifically recognize human PD-1 protein.
Gene name : PDCD1 PD1
Protein Name : Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)

Database connection:

Organism

Gene ID

SwissProt

Background:

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],

Cell localization : Membranous, Cytoplasmic

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