Signaling pathway

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ITGAE (light chain, Cleaved-Arg177) rabbit pAb

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Article Number: PK0142
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: ITGAE
Application: WB, IHC
Reactivity : Human, Rat, Mouse,
MW(Observed) : 17 kD, 128 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-2000;IHC 1:50-300
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : This antibody detects endogenous levels of Human ITGAE (light chain, Cleaved-Arg177, protein was cleaved amino acid sequence between 177-178 )
Gene name : ITGAE
Protein Name : ITGAE (light chain, Cleaved-Arg177)
Alias : Integrin alpha-E; HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD antigen CD103; [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]

Database connection:

Organism

Gene ID

SwissProt

Background:

integrin subunit alpha E(ITGAE) Homo sapiens Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008],

Cell localization : Membrane; Single-pass type I membrane protein.

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