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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PL0351
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Target： Claudin 11
Application： WB, IF, ELISA
Reactivity ： Human,Mouse,Rat
MW(CalcμLated) ： 22 kD
MW(Observed) ： 22 kD
Host Species： Rabbit
Isotype ： IgG, Kappa
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： Protein A
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clone Number ： Monoclonal
Antigen & Target Information
Specificity ： Endogenous
Gene name ： CLDN11
Protein Name ： Claudin-11
Alias ： CLDN11;OSP;OTM;Claudin-11;Oligodendrocyte-specific protein
Background：
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different iso
Cell localization ： Cell junction, tight junction. Cell membrane ; Multi-pass membrane protein .
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Email: pinuofei2017@163.com
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