Signaling pathway

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AMPKβ2 Polyclonal Antibody

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Article Number: PG3215
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: AMPKβ2
Application: World Bank
Reactivity : Human,Mouse,Rat
MW(Observed) : 30 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:1000-2000
Compose : PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clonality : Polyclonal

Antigen & Target Information

Specificity : The antibody detects endogenous AMPKβ2 protein.
Gene name : PRKAB2
Protein Name : 5'-AMP-activated protein kinase subunit beta-2
Alias : PRKAB2;5'-AMP-activated protein kinase subunit beta-2;AMPK subunit beta-2

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],

Cell localization : nucleoplasm, cytosol, nucleotide-activated protein kinase complex,

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