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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PK0110
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Category:
Target： Plasma Kallikrein LC
Application： WB, ELISA, IHC
Reactivity ： Human, Rat, Mouse,
MW(Observed) ： 28 kDa, 70 kDa
Host Species： Rabbit
Isotype ： IgG
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Compose ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process ： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Concentration ： 1 mg/ml
Clonality ： Polyclonal
Antigen & Target Information
Specificity ： This antibody detects endogenous levels of Human Cleaved-Plasma Kallikrein LC (I391, protein was cleaved amino acid sequence between 390-391 )
Gene name ： KLKB1 KLK3
Protein Name ： Plasma Kallikrein LC (Cleaved-I391)
Alias ： Plasma kallikrein; Fletcher factor; Kininogen; Plasma prekallikrein; [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]
Background：
catalytic activity: Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin. disease: Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also called Fletcher factor deficiency. This disorder is a blood coagulation defect. function: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. similarity: Belongs to the peptidase S1 family. similarity: Belongs to the peptidase S1 family. Plasma kallikrein subfamily. similarity: Contains 1 peptidase S1 domain. similarity: Contains 4 apple domains. subunit: The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.
Cell localization ： Secreted.
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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