Signaling pathway

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T-bet (PTR1291) mouse mAb

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Article Number: PH0526
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: TBX21
Application: WB, IF, ELISA
Reactivity : Human,Mouse,
MW(CalcμLated) : 58 kD
MW(Observed) : 62 kD
Host Species: Mouse
Isotype : IgG2a, Kappa

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : Protein G
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Monoclonal
Clone Number : PTR1291

Antigen & Target Information

Specificity : This antibody detects endogenous levels of T-bet protein.
Gene name : TBX21 TBET TBLYM
Protein Name : T-box transcription factor TBX2
Alias : T-box transcription factor TBX21;T-box protein 21;T-cell-specific T-box transcription factor T-bet;Transcription factor TBLYM;

Database connection:

Organism

Gene ID

SwissProt

Background:

T-box 21 (TBX21) Homo sapiens This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008],

Cell localization : Nuclear

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