Signaling pathway

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MAML2 Polyclonal Antibody

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Article Number: PG7875
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: MAML2
Application: WB, ELISA
Reactivity : Human
MW(Observed) : 127 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-2000; ELISA 1:5000-20000
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : MAML2 Polyclonal Antibody detects endogenous levels of protein.
Gene name : MAML2 KIAA1819
Protein Name : Mastermind-like protein 2 (Mam-2)

Database connection:

Organism

Gene ID

SwissProt

Background:

The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the p

Cell localization : Nucleus speckle . Nuclear, in a punctate manner.

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