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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PA0356
Delivery time: 两个月
Price: 100ug/2200
Target： CD22
Application： ELISA, FC
Reactivity ： Human
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： ELISA 1:5000-100000; Flow Cyt 1-2μg/Test
Compose ： Phosphate-buffered solution
Source ： Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
Purification process ： Recombinant Expression and Affinity purified
Storage ： -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration ： Please check the information on the tube
Clonality ： Monoclonal
Clone Number ： PN0574
Antigen & Target Information
Specificity ： This recombinant monoclonal antibody can detects endogenous levels of CD22 protein.
Gene name ： CD22 SIGLEC2
Protein Name ： T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)
Alias ： T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; CD antigen CD3e; CD3 nanobody;
Background：
alternative products: Additional isoforms seem to exist, domain: Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases., function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules., online information: Siglec-2, online information: Siglec-2 [3 Fc Domains] PTM: Phosphorylated on tyrosine residues by LYN., PTM: Phosphorylation of Tyr-762, Tyr-807, and Tyr-822 are involved in binding to SYK, GRB2, and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2, and PIK3R1/PIK3R2., similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family., similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain., similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains., subunit: Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2, and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D, and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2, and SHC1., tissue specificity: B-lymphocytes.,
Cell localization ： Cell membrane; Single-pass type I membrane protein.
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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