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Article Number: PL0499
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Category:
Target： LOX-1
Application： WB, IHC, IF, ELISA
Reactivity ： Human,Mouse,Rat
MW(CalcμLated) ： 31 kDa
MW(Observed) ： 55 kD
Host Species： Rabbit
Isotype ： IgG, Kappa
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： IHC 1:200-1:1000; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： Protein A
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clonality ： Monoclonal
Clone Number ： PT1263R
Antigen & Target Information
Specificity ： Endogenous
Gene name ： OLR1 CLEC8A LOX1
Protein Name ： Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (C-type lectin domain family 8 member A) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (hLOX-1) (Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1, soluble form]
Alias ： Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; C-type lectin domain family 8 member A; Lectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; hLOX-1; Lectin-type oxidized LDL receptor 1; OLR1; CLEC8A; LOX1;
Background：
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010],
Cell localization ： Disease: Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]., Disease: Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. However, its involvement in AD remains unclear: according to some authors (PubMed:12354387, PubMed:12810610, and PubMed:15976314), variations in OLR1 modify the risk of AD, whereas others (PubMed:15000751 and PubMed:15060104) suggest they do not., Domain: The C-type lectin domain mediates the recognition and binding of oxLDL., Domain: The cytoplasmic region is required for subcellular sorting on the cell surface., Function: A receptor that mediates the recognition, internalization, and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions, and apoptosis. Its association with oxLDL triggers NF-kappa-B activation through increased intracellular reactive oxygen species and various pro-atherogenic cellular responses, including reduced nitric oxide (NO) release, monocyte adhesion, and apoptosis. In addition to binding oxLDL, it serves as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. It also plays a role in inflammatory processes by acting as a leukocyte-adhesion molecule at the vascular interface during endotoxin-induced inflammation. Furthermore, it functions as a receptor for advanced glycation end-products (AGEs), activated platelets, monocytes, apoptotic cells, and both Gram-negative and Gram-positive bacteria., Induction: By inflammatory cytokines such as TNF-alpha, IFN-gamma, IL-6, and by pathological conditions like hyperlipidemia, hypertension, and diabetes mellitus. It is up-regulated in atherosclerotic lesions due to oxLDL, reactive oxygen species, and fluid shear stress, suggesting potential involvement in amplifying oxLDL-induced vascular dysfunction., Online information: Oxidized LDL receptor, PTM: N-glycosylated., PTM: Intrachain disulfide bonds prevent N-glycosylation at certain sites., Similarity: Contains one C-type lectin domain., Subcellular location: A secreted form also exists., Subunit: Homodimer; disulfide-linked. May form a hexamer composed of three homodimers. Interacts with HSP70., Tissue specificity: Expressed at high levels in endothelial cells and vascular-rich organs such as placenta, lung, liver, brain, aortic intima, bone marrow, spinal cord, and substantia nigra. Also expressed on the surface of dendritic cells. Widely expressed at intermediate and low levels.
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