Signaling pathway

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CD70 (PN0049) Nb-FC recombinant antibody

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Article Number: PA0678
Delivery time: 现货
Price: 100ug/2200

Detailed Information

Recommended dilution ratio : ELISA 1:5000-100000
Compose : Phosphate-buffered solution
Source : Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
Purification process : Recombinant Expression and Affinity purified
Storage : -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration : Please check the information on the tube
Clonality : Monoclonal
Clone Number : PN0412

Antigen & Target Information

Specificity : This recombinant monoclonal antibody can detects endogenous levels of CD86 protein.
Gene name : CD86 CD28LG2
Protein Name : CD70 antigen (CD27 ligand) (CD27-L) (Tumor necrosis factor ligand superfamily member 7) (CD antigen CD70)
Alias : CD70;CD27L;CD27LG;TNFSF7;CD70 antigen;CD27 ligand;CD27-L;Tumor necrosis factor ligand superfamily member 7;CD antigen CD70;CD70 nanobody;

Database connection:

Organism

Gene ID

SwissProt

Background:

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily.This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding ofThis protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding ofThis protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

Cell localization : Cell membrane; Single-pass type I membrane protein.

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