Product Services
Signaling pathway
-
-
-
Neurodegeneration—A Common Pathway Across Multiple Diseases (0)
-
The AGE–RAGE signaling pathway in diabetic complications (0)
-
PD-L1 Expression and the PD-1 Checkpoint Pathway in Cancer (0)
-
Epithelial Cell Signaling in Helicobacter pylori Infection (0)
-
Glioma-associated Kaposi’s sarcoma-associated herpesvirus infection (0)
Contact Us
Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PL0583
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Target： Glut4
Application： WB, IHC, IF, IP, ELISA
Reactivity ： Human,Mouse,Rat
MW(CalcμLated) ： 55 kD
MW(Observed) ： 55 kD
Host Species： Rabbit
Isotype ： IgG, Kappa
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： Protein A
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clonality ： Monoclonal
Clone Number ： PT1170R
Antigen & Target Information
Specificity ： Endogenous
Gene name ： SLC2A4
Protein Name ： Solute carrier family 2 facilitated glucose transporter member 4
Alias ： SLC2A4;GLUT4;Solute carrier family 2, facilitated glucose transporter member 4;Glucose transporter type 4, insulin-responsive;GLUT-4
Database connection:
Background：
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008],
Cell localization ： Disease: Defects in SLC2A4 may be a cause of noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. Defects in SLC2A4 may be a cause of certain post-receptor defects in NIDDM. The variant in position Ile-383 is found in a small number of NIDDM patients, but seems not to be found in nondiabetic subjects. Function: Insulin-regulated facilitative glucose transporter. miscellaneous: Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation. online information: GLUT4 entry, PTM: Sumoylated. similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. subcellular location: Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration. subunit: Binds to DAXX. Interacts via its N-terminus with SRFBP1. tissue specificity: Skeletal and cardiac muscles; brown and white fat.
Recommended
Relevant Literature
We remain open to communication and look forward to supporting you.
Centered on our primary and secondary antibody products, we have established a strong foothold in the specialized antibody reagent market. Leveraging our independently developed core technology platform and a dedicated R&D and manufacturing team, we provide high‑reliability biological reagents and end‑to‑end technical solutions to universities, research institutes, biopharmaceutical companies, and other customers worldwide.
Support Services. Since its inception, Pinofibio has remained committed to a development philosophy centered on research needs. Through a robust R&D system, stringent quality control, and responsive, efficient service, the company is dedicated to building an antibody product portfolio that spans multiple species and targets, helping researchers overcome technical challenges and driving innovation in the biopharmaceutical industry.
Wuhan Pinofibio Biotechnology Co., Ltd.
Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Xiaohongshu
Experimental Services
Official Account
Antibody Services
微信客服