Signaling pathway

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IRAK-4 Monoclonal Antibody

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Article Number: PH1600
Delivery time: 一周
Price: 100 μL/2200
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Target: IRAQ-4
Application: WB, IHC, IF, Flow Cyt, ELISA
Reactivity : Human,Mouse,Monkey
MW(CalcμLated) : 52 kD
Host Species: Mouse

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-1:2000; IHC 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; IF 1:50-200
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : Affinity purification
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clonality : Monoclonal

Antigen & Target Information

Specificity : IRAK-4 Monoclonal Antibody detects endogenous levels of IRAK-4 protein.
Gene name : IRAK4
Protein Name : Interleukin-1 receptor-associated kinase 4

Database connection:

Organism

Gene ID

SwissProt

Background:

This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],

Cell localization : extracellular space, intracellular, nucleus, cytoplasm, cytosol, plasma membrane, endosome membrane,

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