Signaling pathway

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MICB Polyclonal Antibody

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Article Number: PD1955
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: MICB
Application: IHC, IF, WB
Reactivity : Human
MW(Observed) : 42 kDa
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : IHC 1:50-200; WB 1:500-2000; IF 1:50-200
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : This antibody detects endogenous levels of human MICB
Gene name : MICB PERB11.2
Protein Name : MICB
Alias : MHC class I polypeptide-related sequence B;MIC-B;

Database connection:

Organism

Gene ID

SwissProt

Background:

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],

Cell localization : Cell membrane; Single-pass type I membrane protein. Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.

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