Signaling pathway

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Trk C Monoclonal Antibody

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Article Number: PH1417
Delivery time: 一周
Price: 100 μL/2200
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Target: Track C
Application: WB, IHC, IF, ELISA
Reactivity : Human
MW(CalcμLated) : 94 kD
Host Species: Mouse

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : Affinity purification
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clonality : Monoclonal

Antigen & Target Information

Specificity : Trk C Monoclonal Antibody detects endogenous levels of Trk C protein.
Gene name : NTRK3
Protein Name : NT-3 growth factor receptor
Alias : NTRK3;TRKC;NT-3 growth factor receptor;GP145-TrkC;Trk-C;Neurotrophic tyrosine kinase receptor type 3;TrkC tyrosine kinase

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],

Cell localization : Membrane; Single-pass type I membrane protein.

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