Signaling pathway

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CD197 (PTF0059) Mouse mAb

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Article Number: PR0110
Delivery time: 现货
Price: 100 μL/1500
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Target: CCR7
Application: FC,IF
Reactivity : Human
Host Species: Mouse
Isotype : Mouse IgG1/Kappa

隐藏域元素占位

Detailed Information

Recommended dilution ratio : IF 1:200-1:1000;FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application
Compose : PBS, pH 7.4
Purification process : Protein A
Storage : Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Clone Number : Monoclonal

Antigen & Target Information

Specificity : Endogenous
Gene name : CCR7
Protein Name : C-C chemokine receptor type 7
Alias : CCR7;CMKBR7;EBI1;EVI1;C-C chemokine receptor type 7;C-C CKR-7;CC-CKR-7;CCR-7;BLR2;CDw197;Epstein-Barr virus-induced G-protein coupled receptor 1;EBI1;EBV-induced G-protein coupled receptor 1;MIP-3 beta receptor;CD antigen CD19

Database connection:

Organism

Gene ID

SwissProt

Background:

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014],

Cell localization : Cell membrane; Multi-pass membrane protein.

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