Signaling pathway

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R-Spondin Monoclonal Antibody

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Article Number: PH1462
Delivery time: 一周
Price: 100 μL/2200
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Target: R-Spondin
Application: WB, ELISA
Reactivity : Human
MW(CalcμLated) : 29 kDa
Host Species: Mouse

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : Affinity purification
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clonality : Monoclonal

Antigen & Target Information

Specificity : R-Spondin Monoclonal Antibody detects endogenous levels of R-Spondin protein.
Gene name : RSPO1
Protein Name : R-spondin-1
Alias : RSPO1; R-spondin-1; Roof plate-specific spondin-1; hRspo1

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014],

Cell localization : Secreted . Nucleus . Seems to mainly localize to nucleoli. .

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