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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PL0402
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Target： Mnk1
Application： WB, IF, ELISA
Reactivity ： Human,Mouse
MW(CalcμLated) ： 51 kD
MW(Observed) ： 51 kD
Host Species： Rabbit
Isotype ： IgG, Kappa
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： Protein A
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clonality ： Monoclonal
Clone Number ： PT1363R
Antigen & Target Information
Specificity ： Endogenous
Gene name ： MKNK1
Protein Name ： MAP kinase-interacting serine/threonine-protein kinase 1
Alias ： MKNK1;MNK1;MAP kinase-interacting serine/threonine-protein kinase 1;MAP kinase signal-integrating kinase 1;MAPK signal-integrating kinase 1;Mnk1
Database connection:
Background：
MAP kinase interacting serine/threonine kinase 1(MKNK1) Homo sapiens This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012],
Cell localization ： Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. Enzyme regulation: Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway. Function: May play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. PTM: Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. Similarity: Belongs to the protein kinase superfamily. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Similarity: Contains 1 protein kinase domain. Subunit: Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2, and to the p38 kinases. Tissue specificity: Ubiquitous.
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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