Signaling pathway

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p57 Polyclonal Antibody

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Article Number: PD2650
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: p57
Application: WB, IF, ELISA
Reactivity : Human,Mouse,Rat
MW(Observed) : 32 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-1:2000; ELISA 1:20000; IF 1:50-200
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : p57 Polyclonal Antibody detects endogenous levels of p57 protein.
Gene name : CDKN1C
Protein Name : Cyclin-dependent kinase inhibitor 1C
Alias : CDKN1C;KIP2;Cyclin-dependent kinase inhibitor 1C;Cyclin-dependent kinase inhibitor p57;p57Kip2

Database connection:

Organism

Gene ID

SwissProt

Background:

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010],

Cell localization : Nucleus .

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