Signaling pathway

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CYP11B1/2 Polyclonal Antibody

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Article Number: PD2744
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: CYP11B1/2
Application: WB, ELISA
Reactivity : Human
MW(Observed) : 58 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : CYP11B1/2 Polyclonal Antibody detects endogenous levels of CYP11B1/2 protein.
Gene name : CYP11B1/CYP11B2
Protein Name : Cytochrome P450 11B1 mitochondrial/Cytochrome P450 11B2 mitochondrial
Alias : CYP11B1;S11BH;Cytochrome P450 11B1, mitochondrial;CYPXIB1;Cytochrome P-450c11;Cytochrome P450C11;Steroid 11-beta-hydroxylase;CYP11B2;Cytochrome P450 11B2, mitochondrial;Aldosterone synthase;ALDOS;Aldosterone-synthesizing enzyme;CYPXIB2;Cytochrome P-450Aldo;Cytochrome P-450C18;Steroid 18-hydroxylase

Database connection:

Organism

Gene ID

SwissProt

Background:

cytochrome P450 family 11 subfamily B member 1(CYP11B1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008],

Cell localization : Mitochondrion inner membrane ; Peripheral membrane protein .

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