Signaling pathway

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BNIP-3 Polyclonal Antibody

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Article Number: PD2805
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: BNIP-3
Application: WB, IHC, IF, ELISA
Reactivity : Human,Mouse
MW(Observed) : 22 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : BNIP-3 Polyclonal Antibody detects endogenous levels of BNIP-3 protein.
Gene name : BNIP3
Protein Name : BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Alias : BNIP3;NIP3;BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014],

Cell localization : Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.

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