Signaling pathway

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WWOX Polyclonal Antibody

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Article Number: PD3020
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: WWOX
Application: WB, IHC, IF, ELISA
Reactivity : Human,Mouse
MW(Observed) : 47 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : WWOX Polyclonal Antibody detects endogenous levels of WWOX protein.
Gene name : WWOX
Protein Name : WW domain-containing oxidoreductase
Alias : WWOX;FOR;WOX1;WW domain-containing oxidoreductase;Fragile site FRA16D oxidoreductase

Database connection:

Organism

Gene ID

SwissProt

Background:

WWOX (WW domain containing oxidoreductase) encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. WWOX spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of WWOX is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.

Cell localization : Cytoplasm . Nucleus . Mitochondrion . Golgi apparatus . Partially localizes to the mitochondria (PubMed:14695174). Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus. .

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