Signaling pathway

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UBA2 Polyclonal Antibody

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Article Number: PD3128
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: UBA2
Application: WB, IHC, IF, ELISA
Reactivity : Human,Mouse
MW(Observed) : 71 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : UBA2 Polyclonal Antibody detects endogenous levels of UBA2 protein.
Gene name : UBA2
Protein Name : SUMO-activating enzyme subunit 2
Alias : UBA2;SAE2;UBLE1B;HRIHFB2115;SUMO-activating enzyme subunit 2;Anthracycline-associated resistance ARX;Ubiquitin-like 1-activating enzyme E1B

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010],

Cell localization : Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.

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