Signaling pathway

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Neurofibromin Polyclonal Antibody

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Article Number: PD4605
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: Neurofibromin
Application: WB, IHC
Reactivity : Human,Mouse,Rat
MW(Observed) : 319kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-2000;IHC 1:50-300
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : Neurofibromin Polyclonal Antibody detects endogenous levels of Neurofibromin protein.
Gene name : NF1
Protein Name : Neurofibromin
Alias : NF1; Neurofibromin; Neurofibromatosis-related protein NF-1

Database connection:

Organism

Gene ID

SwissProt

Background:

This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008],

Cell localization : Nucleus . Nucleus, nucleolus .

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