Signaling pathway

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EpoR Polyclonal Antibody

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Article Number: PD5819
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: EpoR
Application: WB, IF, ELISA
Reactivity : Human,Mouse,Rat,Monkey
MW(Observed) : 65 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:40000;Not yet tested in other applications.
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : EpoR Polyclonal Antibody detects endogenous levels of EpoR protein.
Gene name : EPOR
Protein Name : Erythropoietin receptor
Alias : EPOR; Erythropoietin receptor; EPO-R

Database connection:

Organism

Gene ID

SwissProt

Background:

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010],

Cell localization : Cell membrane; Single-pass type I membrane protein.; [Isoform EPOR-S]: Secreted . Secreted and located to the cell surface.

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