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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PD5995
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Target： DOC-1
Application： WB, ELISA
Reactivity ： Human,Mouse
MW(Observed) ： 20 kD
Host Species： Rabbit
Isotype ： IgG
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： WB 1:500-1:2000;ELISA 1:5000;Not yet tested in other applications.
Compose ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Concentration ： 1 mg/ml
Clonality ： Polyclonal
Antigen & Target Information
Specificity ： DOC-1 Polyclonal Antibody detects endogenous levels of DOC-1 protein.
Gene name ： CDK2AP1
Protein Name ： Cyclin-dependent kinase 2-associated protein 1
Alias ： CDK2AP1;CDKAP1;DOC1;Cyclin-dependent kinase 2-associated protein 1;CDK2-associated protein 1;Deleted in oral cancer 1;DOC-1;Putative oral cancer suppressor
Background：
Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) Homo sapiens. The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2)-associated protein that is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2 and targeting CDK2 for proteolysis. This protein has also been shown to interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, suggesting a regulatory role in DNA replication during the S-phase of the cell cycle. Furthermore, this protein forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex, which epigenetically regulates embryonic stem cell differentiation. Thus, this gene plays a role in both cell-cycle regulation and epigenetic regulation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Cell localization ： nucleus, perinuclear region of cytoplasm,
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Wuhan Pinofibio Biotechnology Co., Ltd.
Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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