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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PD6354
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Target： Clusterin
Application： WB, IHC, IF, ELISA
Reactivity ： Human,Mouse,Rat
MW(Observed) ： 52 kD
Host Species： Rabbit
Isotype ： IgG
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
Compose ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Concentration ： 1 mg/ml
Clonality ： Polyclonal
Antigen & Target Information
Specificity ： Clusterin Polyclonal Antibody detects endogenous levels of Clusterin protein.
Gene name ： CLU
Protein Name ： Clusterin
Alias ： CLU;APOJ;CLI;KUB1;AAG4;Clusterin;Aging-associated gene 4 protein;Apolipoprotein J;Apo-J;Complement cytolysis inhibitor;CLI;Complement-associated protein SP-40;40;Ku70-binding protein 1;NA1/NA2;Testosterone-repressed prostate m
Database connection:
Background：
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011],
Cell localization ： [Isoform 1]: Secreted. Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. .; [Isoform 4]: Cytoplasm. Maintains cytoplasmic localization in both stressed and unstressed cells. .; [Isoform 6]: Cytoplasm. Maintains cytoplasmic localization in both stressed and unstressed cells. .; Nucleus. Cytoplasm. Mitochondrial membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Mitochondrion. Mitochondrial membrane. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular stress (PubMed:17451556). Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins (PubMed:20068069). Detected at the mitochondrial membrane upon induction of apoptosis (PubMed:17689225). Under ER stress, an immaturely glycosylated pre-secreted form retrotranslocates from the endoplasmic reticulum (ER)-Golgi network to the cytoplasm to localize in the mitochondria through HSPA5 interaction (PubMed:22689054). ER stress reduces secretion (PubMed:22689054). Under this stress, minor amounts of non-secreted forms accumulate in the cytoplasm (PubMed:24073260, PubMed:22689054, PubMed:17451556). Non-secreted forms arise primarily from failed translocation, alternative splicing, or non-canonical initiation start codons (PubMed:24073260, PubMed:12551933). .
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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