Signaling pathway

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CD3-ε Polyclonal Antibody

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Article Number: PD6537
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Detailed Information

Recommended dilution ratio : WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : CD3-ε Polyclonal Antibody detects endogenous levels of CD3-ε protein.
Gene name : CD3E
Protein Name : T-cell surface glycoprotein CD3 epsilon chain
Alias : CD3E; T3E; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; CD antigen CD3e

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008],

Cell localization : Cell membrane ; Single-pass type I membrane protein .

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