Product Services
Signaling pathway
-
-
-
Neurodegeneration—A Common Pathway Across Multiple Diseases (0)
-
The AGE–RAGE signaling pathway in diabetic complications (0)
-
PD-L1 Expression and the PD-1 Checkpoint Pathway in Cancer (0)
-
Epithelial Cell Signaling in Helicobacter pylori Infection (0)
-
Glioma-associated Kaposi’s sarcoma-associated herpesvirus infection (0)
Contact Us
Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PD6831
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Target： ATP7B
Application： IHC, IF, ELISA
Reactivity ： Human,Mouse,Rat
MW(CalcμLated) ： 157 kD
Host Species： Rabbit
Isotype ： IgG
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications.
Compose ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Concentration ： 1 mg/ml
Clonality ： Polyclonal
Antigen & Target Information
Specificity ： ATP7B Polyclonal Antibody detects endogenous levels of ATP7B protein.
Gene name ： ATP7B
Protein Name ： Copper-transporting ATPase 2
Alias ： ATP7B;PWD;WC1;WND;Copper-transporting ATPase 2;Copper pump 2;Wilson disease-associated protein
Background：
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq, Jul 2008],
Cell localization ： Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome. Predominantly found in the trans-Golgi network (TGN). Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicles when cells are exposed to elevated copper levels, and then recycles back to the trans-Golgi network when copper is removed (PubMed:10942420). ; [Isoform 1]: Golgi apparatus membrane; Multi-pass membrane protein.; [Isoform 2]: Cytoplasm.; [WND/140 kDa]: Mitochondrion.
Recommended
Relevant Literature
We remain open to communication and look forward to supporting you.
Centered on our primary and secondary antibody products, we have established a strong foothold in the specialized antibody reagent market. Leveraging our independently developed core technology platform and a dedicated R&D and manufacturing team, we provide high‑reliability biological reagents and end‑to‑end technical solutions to universities, research institutes, biopharmaceutical companies, and other customers worldwide.
Support Services. Since its inception, Pinofibio has remained committed to a development philosophy centered on research needs. Through a robust R&D system, stringent quality control, and responsive, efficient service, the company is dedicated to building an antibody product portfolio that spans multiple species and targets, helping researchers overcome technical challenges and driving innovation in the biopharmaceutical industry.
Wuhan Pinofibio Biotechnology Co., Ltd.
Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Xiaohongshu
Experimental Services
Official Account
Antibody Services
微信客服