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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PD7169
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Target： A1Up
Application： WB, IHC, IF, ELISA
Reactivity ： Human,Mouse
MW(Observed) ： 54 kD
Host Species： Rabbit
Isotype ： IgG
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Compose ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Concentration ： 1 mg/ml
Clonality ： Polyclonal
Antigen & Target Information
Specificity ： A1Up Polyclonal Antibody detects endogenous levels of A1Up protein.
Gene name ： UBQLN4
Protein Name ： Ubiquilin-4
Alias ： UBQLN4;C1orf6;CIP75;UBIN;Ubiquilin-4;Ataxin-1 interacting ubiquitin-like protein;A1Up;Ataxin-1 ubiquitin-like-interacting protein A1U;Connexin43-interacting protein of 75 kDa;CIP75
Background：
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 UBA domain. Similarity: Contains 1 ubiquitin-like domain. Subcellular location: May associate with the endoplasmic reticulum. Subunit: Homodimer. Binds SCA1. Binds signal sequences of proteins that are targeted to the endoplasmic reticulum. Tissue specificity: Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.
Cell localization ： Nucleus . Cytoplasm . Chromosome . Endoplasmic reticulum . Cytoplasm, perinuclear region . Cytoplasmic vesicle, autophagosome . Colocalizes with the proteasome, both in nucleus and cytoplasm (PubMed:15280365). Exported from the nucleus following interaction with DESI1/POST (PubMed:29666234). In response to DNA damage and phosphorylation at Ser-318 by ATM, localizes to the nucleus and is recruited to sites of DNA damage (PubMed:30612738). .
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Wuhan Pinofibio Biotechnology Co., Ltd.
Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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