Signaling pathway

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FGFR1/2 (Phospho Tyr730/733) Rabbit pAb

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Article Number: PF0159
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: FGF Receptor
Application: IHC, WB
Reactivity : Human,Mouse,Rat
MW(Observed) : 120 kD
Host Species: Rabbit

隐藏域元素占位

Detailed Information

Modify-Modification : Phospho
Recommended dilution ratio : WB 1:500-2000; IHC 1:50-200
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : This antibody detects endogenous levels of FGFR1/2 (Phospho Tyr730/733) Rabbit pAb at Human, Mouse,Rat
Gene name : FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR FGFR2 BEK
Protein Name : Fibroblast growth factor receptor 1 (FGFR-1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Alias : FGFR1;BFGFR;CEK;FGFBR;FLG;FLT2;HBGFR;Fibroblast growth factor receptor 1;FGFR-1;Basic fibroblast growth factor receptor 1;BFGFR;bFGF-R-1;Fms-like tyrosine kinase 2;FLT-2;N-sam;Proto-oncogene c-Fgr;CD antigen CD331;FGFR2;BE

Database connection:

Organism

Gene ID

SwissProt

Background:

fibroblast growth factor receptor 1(FGFR1) Homo sapiens The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome,

Cell localization : Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.

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