Signaling pathway

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TIP60 (phospho Ser86) Polyclonal Antibody

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Article Number: PF1574
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: TIP60
Application: WB, ELISA, IHC
Reactivity : Human,Mouse
MW(Observed) : 65 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Modify-Modification : Phospho
Recommended dilution ratio : WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : Phospho-TIP60 (S86) Polyclonal Antibody detects endogenous levels of TIP60 protein only when phosphorylated at S86.
Gene name : KAT5
Protein Name : Histone acetyltransferase KAT5
Alias : KAT5;HTATIP;TIP60;Histone acetyltransferase KAT5;60 kDa Tat-interactive protein;Tip60;Histone acetyltransferase HTATIP;HIV-1 Tat interactive protein;Lysine acetyltransferase 5;cPLA;2;-interacting protein

Database connection:

Organism

Gene ID

SwissProt

Background:

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008],

Cell localization : Nucleus . Chromosome . Cytoplasm . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle pole . Nucleus, nucleolus . Cytoplasm, perinuclear region . Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies (PubMed:11262386). Transiently localizes to kinetochores in early mitosis (PubMed:26829474). Localizes to spindle poles when chromosomes align during metaphase (PubMed:34608293). Localizes in the cytoplasm and nucleus of round spermatids (By similarity). .

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