Signaling pathway

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Tubulin α (Acetyl Lys40) Polyclonal Antibody

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Article Number: PS0258
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560

Detailed Information

Modify-Modification : Acetyl
Recommended dilution ratio : WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : Acetyl-Tubulin α (K40) Polyclonal Antibody detects endogenous levels of Tubulin α protein only when acetylated at K40.
Gene name : TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA4A
Protein Name : Tubulin alpha-1A chain/Tubulin alpha-1B chain/Tubulin alpha-1C chain/Tubulin alpha-3C/D chain/Tubulin alpha-4A chain
Alias : TUBA1A;TUBA3;Tubulin alpha-1A chain;Alpha-tubulin 3;Tubulin B-alpha-1;Tubulin alpha-3 chain;TUBA1B;Tubulin alpha-1B chain;Alpha-tubulin ubiquitous;Tubulin K-alpha-1;Tubulin alpha-ubiquitous chain;TUBA1C;TUBA6;Tubulin alpha-6 chain;TUBA3C;TUBA2;TUBA3D;Tubulin alpha-3C/D chain;Alpha-tubulin 2;Alpha-tubulin 3C/D;Tubulin alpha-2 chain;TUBA4A;TUBA1;Tubulin alpha-4A chain;Alpha-tubulin 1;Testis-specific alpha-tubulin;

Database connection:

Organism

Gene ID

SwissProt

Background:

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.

Cell localization : Cytoplasm, cytoskeleton.

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