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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PK0244
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Category:
Target： Notch 2
Application： IF, WB, IHC, ELISA
Reactivity ： Human,Mouse,Rat
MW(Observed) ： 110(cleaved)kD
Host Species： Rabbit
Isotype ： IgG
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： IF 1:50-200;WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;Not yet tested in other applications;
Compose ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Concentration ： 1 mg/ml
Clonality ： Polyclonal
Antigen & Target Information
Specificity ： Cleaved-Notch 2 (D1733) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 2 protein resulting from cleavage adjacent to D1733.
Gene name ： NOTCH2
Protein Name ： Neurogenic locus notch homolog protein 2
Alias ： NOTCH2;Neurogenic locus notch homolog protein 2;Notch 2;hN2
Database connection:
Background：
notch 2(NOTCH2) Homo sapiens This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cle
Cell localization ： [Notch 2 extracellular truncation]: Cell membrane; Single-pass type I membrane protein. [Notch 2 intracellular domain]: Nucleus; Cytoplasm. Following proteolytical processing, NICD is translocated to the nucleus. It is retained in the cytoplasm by TCIM (PubMed:25985737).
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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