Signaling pathway

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Neurofilament (ABT456) mouse mAb

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Article Number: PH0141
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: NF-L
Application: IHC, ELISA
Reactivity : Human,Mouse,Rat,
MW(CalcμLated) : 68 kD
MW(Observed) : 68 kD
Host Species: Mouse
Isotype : IgG1, Kappa

隐藏域元素占位

Detailed Information

Recommended dilution ratio : IHC 1:200-400; ELISA 1:500-5000
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clonality : Monoclonal
Clone Number : ABT456

Antigen & Target Information

Specificity : The antibody can specifically recognize human Neurofilament protein, especilaly NF-L protein.
Gene name : NEFL NF68 NFL
Protein Name : Neurofilament light polypeptide; NF-L; Neurofilament triplet L protein; 68 kDa neurofilament protein;
Alias : Neurofilament light polypeptide; NF-L; 68 kDa neurofilament protein; Neurofilament triplet L protein;

Database connection:

Organism

Gene ID

SwissProt

Background:

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008],

Cell localization : Cytoplasmic

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