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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PL0244
Delivery time: 现货
Price: 100 μL/1800
Category:
Target： p35
Application： WB, IHC, IF, ELISA
Reactivity ： Human,Mouse,Rat
MW(CalcμLated) ： 34 kD
MW(Observed) ： 34 kD
Host Species： Rabbit
Isotype ： IgG, Kappa
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： Protein A
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clone Number ： Monoclonal
Antigen & Target Information
Specificity ： Endogenous
Gene name ： CDK5R1
Protein Name ： Cyclin-dependent kinase 5 activator 1
Alias ： CDK5R1;CDK5R;NCK5A;Cyclin-dependent kinase 5 activator 1;CDK5 activator 1;Cyclin-dependent kinase 5 regulatory subunit 1;TPKII regulatory subunit;[Cleaved into: Cyclin-dependent kinase 5 activator 1, p35;p35;Cyclin-dependent kinase 5 activator 1, p25;p25;Tau protein kinase II 23 kDa subunit;p23;]
Database connection:
Background：
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008],
Cell localization ： [Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, neuron projection. In primary cortical neurons, p35 is present in the peripheries and nerve terminals. [Cyclin-dependent kinase 5 activator 1, p25]: Nucleus; Cytoplasm, perinuclear region; Perikaryon. The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, specifically to nuclear and perinuclear regions (PubMed:18507738). In primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites (PubMed:18507738).
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Email: pinuofei2017@163.com
TEL: 15392937510
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