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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PL0535
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Category:
Target： ROCK2
Application： WB, IF, ELISA
Reactivity ： Human,Mouse,Rat
MW(CalcμLated) ： 161 kD
MW(Observed) ： 161 kD
Host Species： Rabbit
Isotype ： IgG, Kappa
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： Protein A
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clonality ： Monoclonal
Clone Number ： PT1227R
Antigen & Target Information
Specificity ： Endogenous
Gene name ： ROCK2 KIAA0619
Protein Name ： Rho-associated protein kinase 2
Alias ： ROCK2;KIAA0619;Rho-associated protein kinase 2;Rho kinase 2;Rho-associated;coiled-coil-containing protein kinase 2;Rho-associated, coiled-coil-containing protein kinase II;ROCK-II;p164 ROCK-2
Database connection:
Background：
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008],
Cell localization ： Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Enzyme regulation: Activated by RHOA binding. Function: Protein kinase that phosphorylates a large number of important signaling proteins, thereby regulating the assembly of the actin cytoskeleton. Promotes formation of stress fibers and focal adhesion complexes. Plays a role in smooth muscle contraction. Miscellaneous: Inhibited by Y-27632. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Similarity: Contains 1 AGC-kinase C-terminal domain. Similarity: Contains 1 PH domain. Similarity: Contains 1 phorbol-ester/DAG-type zinc finger. Similarity: Contains 1 protein kinase domain. Similarity: Contains 1 REM (Hr1) repeat. Subcellular location: Cytoplasmic, associated with actin microfilaments and the plasma membrane. Subunit: Homodimer. Binds RHOA that has been activated by GTP binding. Binds IRS1, RHOB, and RHOC.
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Email: pinuofei2017@163.com
TEL: 15392937510
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