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Signaling pathway
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The AGE–RAGE signaling pathway in diabetic complications (0)
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PL0556
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Target： HMGA1
Application： WB, IHC, IF, ELISA
Reactivity ： Human,Mouse,Rat
MW(CalcμLated) ： 12 kD
MW(Observed) ： 18kD
Host Species： Rabbit
Isotype ： IgG, Kappa
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： IHC 1:1000-1:4000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： Protein A
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clonality ： Monoclonal
Clone Number ： PT1205R
Antigen & Target Information
Specificity ： Endogenous
Gene name ： HMGA1 HMGIY
Protein Name ： High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R)
Alias ： High mobility group protein HMG-I/HMG-Y;HMG-I;Y;High mobility group AT-hook protein 1;High mobility group protein A1;High mobility group protein R;
Database connection:
Background：
This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016],
Cell localization ： Disease: A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51L1. Function: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. Mass spectrometry: With 1 acetyl and 2 phosphate groups PubMed:15302935, mass spectrometry: With 1 acetyl and 3 phosphate groups PubMed:15302935, mass spectrometry: With 1 acetyl, 1 methyl and 2 phosphate groups PubMed:15302935, mass spectrometry: With 1 acetyl, 1 methyl and 3 phosphate groups PubMed:15302935, mass spectrometry: With 1 acetyl, 2 methyl and 2 phosphate groups PubMed:15302935, mass spectrometry: With 1 acetyl, 2 methyl and 3 phosphate groups PubMed:15302935, PTM: Constitutively phosphorylated on two or three sites. Phosphorylated upon DNA damage, probably by ATM or ATR. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoform HMG-Y can be phosphorylated by HIPK2. PTM: HMG-Y is not methylated. PTM: Methylation at Arg-58 is mutually exclusive with methylation at Arg-60. Similarity: Belongs to the HMGA family. Similarity: Contains 3 A.T hook DNA-binding domains. Subunit: Interacts with HIPK2 (By similarity). Interacts with HIV-1 pre-integration complex.
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