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Signaling pathway
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Article Number: PL1366
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Category:
Target： ROCK1
Application： WB, IHC, IF, IP, ELISA
Reactivity ： Human,Mouse,Rat,
MW(CalcμLated) ： 158 kD
MW(Observed) ： 158 kD
Host Species： Rabbit
Isotype ： IgG, Kappa
Conjugate ： Unmodified
隐藏域元素占位
Detailed Information
Recommended dilution ratio ： IHC 1:200-1:1000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200,
Compose ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process ： Protein A
Storage ： -15°C to -25°C/1 year(Do not lower than -25°C
Clonality ： Monoclonal
Clone Number ： PT0305R
Antigen & Target Information
Specificity ： Endogenous
Gene name ： >>cGMP-PKG signaling pathway; >>cAMP signaling pathway; >>Chemokine signaling pathway; >>Sphingolipid signaling pathway; >>Vascular smooth muscle contraction; >>TGF-beta signaling pathway; >>Axon guidance; >>Focal adhesion; >>Tight junction; >>Platelet activation; >>Leukocyte transendothelial migration; >>Regulation of actin cytoskeleton; >>Oxytocin signaling pathway; >>Pathogenic Escherichia coli infection; >>Shigellosis; >>Yersinia infection; >>Human cytomegalovirus infection; >>Pathways in cancer; >>Proteoglycans in cancer; >>MicroRNAs in cancer
Protein Name ： ROCK1
Alias ： ROCK1; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated; coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK
Database connection:
Background：
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015],
Cell localization ： Cytoplasm, Membrane
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TEL: 15392937510
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