Signaling pathway

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PGI2 synthase Polyclonal Antibody

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Article Number: PD4088
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: PGI2 synthase
Application: WB, ELISA, IHC
Reactivity : Human,Mouse,Rat
MW(Observed) : 57 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : PGI2 synthase Polyclonal Antibody detects endogenous levels of PGI2 synthase protein.
Gene name : PTGIS
Protein Name : Prostacyclin synthase
Alias : PTGIS;CYP8;CYP8A1;Prostacyclin synthase;Prostaglandin I2 synthase

Database connection:

Organism

Gene ID

SwissProt

Background:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008],

Cell localization : Endoplasmic reticulum membrane ; Single-pass membrane protein .

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