Signaling pathway

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FILA Polyclonal Antibody

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Article Number: PG5878
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: FILA
Application: IHC,IF
Reactivity : Human,Mouse
MW(Observed) : 446 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : IHC 1:50-300; IF 1:50-200
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : FILA Polyclonal Antibody detects endogenous levels of protein.
Gene name : FLG
Protein Name : Filaggrin

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009],

Cell localization : Cytoplasmic granule . In the stratum granulosum of the epidermis, localized within keratohyalin granules (PubMed:1429717). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1 (PubMed:21531719). .

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