Signaling pathway

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Vinculin (PT2221) mouse mAb

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Article Number: PH0594
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: Vinculin
Application: WB, IF, ELISA
Reactivity : Human,Mouse,Rat,
MW(CalcμLated) : 124 kD
MW(Observed) : 124 kD
Host Species: Mouse
Isotype : IgG2a, Kappa

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : Protein G
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clonality : Monoclonal
Clone Number : PT2221

Antigen & Target Information

Specificity : This antibody detects endogenous levels of Vinculin protein.
Gene name : VCL
Protein Name : Vinculin
Alias : VCL;Vinculin;Metavinculin

Database connection:

Organism

Gene ID

SwissProt

Background:

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008],

Cell localization : Membranous, Cytoplasmic

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