Signaling pathway

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Cleaved PARP Monoclonal Antibody(Mix)

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Article Number: PH0826
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: PARP
Application: IF, WB, IHC,
Reactivity : Human
MW(Observed) : 116.89 kD
Host Species: Mouse

隐藏域元素占位

Detailed Information

Recommended dilution ratio : IF 1:50-200; WB 1:2000-5000; IHC 1:50-300
Compose : PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Purification process : The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clonality : Monoclonal

Antigen & Target Information

Specificity : The antibody detects endogenous pro and active PARP protein.
Gene name : PARP1
Protein Name : Poly [ADP-ribose] polymerase 1
Alias : PARP1;ADPRT;PPOL;Poly [ADP-ribose] polymerase 1;PARP-1;ADP-ribosyltransferase diphtheria toxin-like 1;ARTD1;NAD;+;ADP-ribosyltransferase 1;ADPRT 1;Poly[ADP-ribose] synthase 1

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008],

Cell localization : Nucleus . Nucleus, nucleolus . Chromosome . Localizes to sites of DNA damage. .

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