Signaling pathway

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CD278 (PN0066) Nb-FC recombinant antibody

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Article Number: PA0583
Delivery time: 两个月
Price: 100ug/2200
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Target: CD366/TIM-3
Application: ELISA
Reactivity : Human

隐藏域元素占位

Detailed Information

Recommended dilution ratio : ELISA 1:5000-100000
Compose : Phosphate-buffered solution
Source : Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
Purification process : Recombinant Expression and Affinity purified
Storage : -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration : Please check the information on the tube
Clonality : Monoclonal
Clone Number : PN0581

Antigen & Target Information

Specificity : This recombinant monoclonal antibody can detects endogenous levels of CD366/TIM-3 protein.
Gene name : HAVCR2 TIM3 TIMD3
Protein Name : Inducible T-cell costimulator (Activation-inducible lymphocyte immunomediatory molecule) (CD antigen CD278)
Alias : ICOS;AILIM;Inducible T-cell costimulator;Activation-inducible lymphocyte immunomediatory molecule;CD278;CD278 nanobody;ICOS nanobody;

Database connection:

Organism

Gene ID

SwissProt

Background:

The protein encoded byThis gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases.This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

Cell localization : Membrane; Single-pass type I membrane protein. Cell junction. Cell membrane. Localizes to the immunological synapse between CD8+ T-cells and target cells.

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