Signaling pathway

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KGP1 Polyclonal Antibody

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Article Number: PG6847
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: KGP1
Application: WB, ELISA
Reactivity : Human,Mouse
MW(Observed) : 73 kD
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-2000; ELISA 1:5000-20000
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : KGP1 Polyclonal Antibody detects endogenous levels of protein.
Gene name : PRKG1 PRKG1B PRKGR1A PRKGR1B
Protein Name : cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (cGMP-dependent protein kinase I) (cGKI)

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-bindin

Cell localization : Cytoplasm . Colocalized with TRPC7 in the plasma membrane. .

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