Signaling pathway

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PGC-1α Monoclonal Antibody

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Article Number: PH1495
Delivery time: 一周
Price: 100 μL/2200
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Target: PGC-1α
Application: WB, ELISA
Reactivity : Human
MW(CalcμLated) : 91kD
Host Species: Mouse

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : Affinity purification
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clonality : Monoclonal

Antigen & Target Information

Specificity : PGC-1α Monoclonal Antibody detects endogenous levels of PGC-1α protein.
Gene name : PPARGC1A
Protein Name : Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Alias : PPARGC1A;LEM6;PGC1;PGC1A;PPARGC1;Peroxisome proliferator-activated receptor gamma coactivator 1-alpha;PGC-1-alpha;PPAR-gamma coactivator 1-alpha;PPARGC-1-alpha;Ligand effect modulator 6

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008],

Cell localization : [Isoform 1]: Nucleus . Nucleus, PML body .; [Isoform B4]: Nucleus .; [Isoform B4-8a]: Cytoplasm . Nucleus .; [Isoform B5]: Nucleus . Nucleus, PML body .; [Isoform 9]: Nucleus .

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