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Signaling pathway
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Neurodegeneration—A Common Pathway Across Multiple Diseases (0)
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The AGE–RAGE signaling pathway in diabetic complications (0)
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PD-L1 Expression and the PD-1 Checkpoint Pathway in Cancer (0)
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Glioma-associated Kaposi’s sarcoma-associated herpesvirus infection (0)
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Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
Detailed Information
Recommended dilution ratio ： ELISA 1:5000-100000
Compose ： Phosphate-buffered solution
Source ： Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
Purification process ： Recombinant Expression and Affinity purified
Storage ： -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration ： Please check the information on the tube
Clonality ： Monoclonal
Clone Number ： PN0401
Antigen & Target Information
Specificity ： This recombinant monoclonal antibody can detects endogenous levels of CD33 protein.
Gene name ： CD33 SIGLEC3
Protein Name ： Natural cytotoxicity triggering receptor 3 (Activating natural killer receptor p30) (Natural killer cell p30-related protein) (NK-p30) (NKp30) (CD antigen CD337)
Alias ： 1C7 antibody; Activating natural killer receptor p30 antibody; Activating NK A1 receptor antibody; CD337 antibody; CD337 antigen antibody; LY117 antibody; Lymphocyte antigen 117 antibody; MALS antibody; Natural cytotoxicity triggering receptor 3 antibody; Natural killer cell p30 related protein antibody; Natural killer cell p30-related protein antibody; Ncr3 antibody; NCTR3_HUMAN antibody; NK-p30 antibody; NKp30 antibody; CD337 nanobody;
Background：
domain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM).This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).,online information:Siglec-3,PTM:Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.,tissue specificity:Monocytic/myeloid lineage cells.,
Cell localization ： [Isoform CD33M]: Cell membrane; Single-pass type I membrane protein. [Isoform CD33m]: Peroxisome. The CD33m isoform does not localize to cell surfaces but instead accumulates in peroxisomes.
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Centered on our primary and secondary antibody products, we have established a strong foothold in the specialized antibody reagent market. Leveraging our independently developed core technology platform and a dedicated R&D and manufacturing team, we provide high‑reliability biological reagents and end‑to‑end technical solutions to universities, research institutes, biopharmaceutical companies, and other customers worldwide.
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Wuhan Pinofibio Biotechnology Co., Ltd.
Address: 14th Floor, Building A, Wuhan Guoying Seed Industry Building, No. 666, Shendun Fourth Road, Jiangxia District, Wuhan, Hubei Province
Email: pinuofei2017@163.com
TEL: 15392937510
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