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Article Number: PF0696
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
Target: GRK 2
Application: WB, ELISA
Reactivity : Human,Mouse,Rat
MW(Observed) : 80 kD
Host Species: Rabbit
Isotype : IgG
隐藏域元素占位
Detailed Information
Modify-Modification : Phospho
Recommended dilution ratio : WB 1:500-2000; ELISA 1:10000-20000
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal
Antigen & Target Information
Specificity : This detects endogenous levels of GRK2 (Phospho-Ser685)
Gene name : ADRBK1 BARK BARK1 GRK2
Protein Name : Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (G-protein coupled receptor kinase 2)
Alias : ADRBK1;BARK;BARK1;GRK2;Beta-adrenergic receptor kinase 1;Beta-ARK-1;G-protein coupled receptor kinase 2
Background:
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008],


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