Signaling pathway

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AGT Monoclonal Antibody

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Article Number: PH1856
Delivery time: 一周
Price: 100 μL/2200
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Target: AGT
Application: WB, ELISA
Reactivity : Human
MW(CalcμLated) : 52 kD
Host Species: Mouse

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
Compose : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process : Affinity purification
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Clonality : Monoclonal

Antigen & Target Information

Specificity : AGT Monoclonal Antibody detects endogenous levels of AGT protein.
Gene name : AGT
Protein Name : Angiotensinogen
Alias : AGT;SERPINA8;Angiotensinogen;Serpin A8

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008],

Cell localization : Secreted.

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