Signaling pathway

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NACA Polyclonal Antibody

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Article Number: PG8661
Delivery time: 现货
Price: 50 μL/960; 100 μL/1600; 200 μL/2560
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Target: NACA
Application: WB, ELISA
Reactivity : Human,Mouse,Rat
MW(Observed) : 23 kDa
Host Species: Rabbit
Isotype : IgG

隐藏域元素占位

Detailed Information

Recommended dilution ratio : WB 1:500-2000; ELISA 1:5000-20000
Compose : PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Purification process : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage : -15°C to -25°C/1 year(Do not lower than -25°C
Concentration : 1 mg/ml
Clonality : Polyclonal

Antigen & Target Information

Specificity : NACA Polyclonal Antibody detects endogenous levels of protein.
Gene name : NACA HSD48
Protein Name : Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2)
Alias : NACA;HSD48;Nascent polypeptide-associated complex subunit alpha;NAC-alpha;Alpha-NAC;allergen Hom s 2

Database connection:

Organism

Gene ID

SwissProt

Mouse
Background:

This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016],

Cell localization : Cytoplasm . Nucleus . The heterodimer is located mainly in the cytosol, and the homodimer in the nucleus. .

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